Cisplatin, etoposide, bleomycin first-line therapy and early resection of residual tumor in far-advanced germinal testis cancer

摘要: Forty consecutive patients with far-advanced germinal testis tumors (lymph node metastases greater than 10 cm, pulmonary nodules 5 extrapulmonary spread, alpha-fetoprotein 1000 ng/ml, human chorionic gonadotropin 50,000 mIU/ml) were treated five courses of cisplatin, etoposide, and bleomycin (PEB). Twenty-five underwent surgery for the removal residual masses after first three inductions. Fibrotic-necrotic tissue was resected in 11 cases, 12 had mature teratoma, cancer found 2. After combined-modality treatment, 37 (82.5%) entered complete remission (CR): 25 (62.5%) PEB (30%) tumor. One patient progressed on therapy, two others incomplete resection disease. Hematologic toxicity moderate gastrointestinal very mild. a median follow-up period 24 months (range, 13-40), 33 remain continuously disease-free, 4 experienced relapse. Only one these salvaged further chemotherapy. First-line therapy combined early tumor induced high continuous CR rate cancer, moderate.