Development and validation of a confirmatory method for the determination of tranquilisers and a β-blocker in porcine and bovine kidney by LC-MS/MS
作者： C. Bock , C.S. Stachel
DOI: 10.1080/19440049.2013.795292
关键词: Ethyl acetate 、 Extraction (chemistry) 、 Azaperone 、 Acepromazine 、 Chemistry 、 Metabolite 、 Carazolol 、 Chromatography 、 Beta-adrenergic blocking agent 、 Residue (complex analysis)
摘要: A method for the confirmation of tranquilisers azaperone and its metabolite azaperol, chlorpromazine, propionylpromazine acepromazine, haloperidol, xylazine β-blocker carazolol in porcine bovine kidney with LC-MS/MS was developed. Various solvents extraction techniques different ways clean-up were tested verified incurred pig from an animal study. The best efficiency reached by a mixture ammonia ethyl acetate overhead shaking without SPE clean-up. optimised twofold sample validated according to Commission Decision 2002/657/EC matrix-comprehensive in-house validation supported InterVal software, taking into account defined MRLs recommended concentrations. can be used residue control above-mentioned analytes food-producing animals accordance Council Directive 96/23/EC.
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