Suppression of experimental autoimmune myocarditis by sodium fusidate (fusidin).

摘要: Abstract Fusidic acid and its sodium salt fusidate (fusidin) are widely used antibiotics that possess immunomodulating properties. It has been shown fusidin ameliorates the course of several organ-specific immunoinflammatory diseases thus we investigated effect on myosin-induced experimental autoimmune myocarditis (EAM) in rats, a well-established animal model for human giant cell postmyocarditis dilated cardiomyopathy (DCM). Fusidin at doses 80 mg kg −1 was administrated i.m. to male Dark Agouti (DA) either from days 0 10 (early treatment group), or 20 (late group) after induction EAM. Efficacy determined day 21 EAM development. observed both early late with markedly ameliorated clinical, histological immunohistochemical signs disease. The treated rats had significantly decreased incidence EAM, heart weight weight/body ratio (Hw/Bw) compared untreated animals. In contrast severe myocardial damage cellular infiltration there only focal inflammatory cells myocardium rats. groups mean microscopic score lower vehicle-treated addition, number CD4+, ED1+ OX6+ fusidin-treated than group. present findings suggest exhibited therapeutical