High colloid oncotic pressure priming of cardiopulmonary bypass in neonates and infants: implications on haemofiltration, weight gain and renal function

摘要: Objective: To evaluate the influence of high colloid oncotic pressure (COP) priming cardiopulmonary bypass (CPB) on fluid balances, haemofiltration, capillary leakage and renal function in neonates infants. Methods: Twenty or infants underwent heart surgery using CPB were randomised two groups. For group 1 (FFP-group) a blood with fresh frozen plasma (FFP, low pressure) was chosen,forgroup2(HA-group)a bloodprimingcontainingFFPandhumanalbumin20%(HA)torealisehigheroncoticpressureswassubstituted.All patients monitored before, during 6 h after CPB. We measured weights, transfusion volumes, pressures, inflammatory parameters (c-reactive protein, interleukin-6, interleukin-8, thrombocytes, leucocytes) (creatinine clearances, protein losses). Results: Patient’s demographics operational procedures comparable both groups no further differences operation regarding palliation correction. Colloid pressures solutions higher HA-group (28 mmHg 4.9) than FFP-group (6 1.3, p < 0.001). Relative weight gain as marker (2% 4.5) significantly lower post (8% 8.0, = 0.015). Haemofiltration rates (569 ml 197 vs 282 157, 0.002) There creatinine clearances end Renal losses elevated without any inter-group Conclusion: Addition concentrated human albumin to fluids paediatric cardiac leads less even Supplementing undergoing does not affect more severely priming. # 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.