Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors.
作者： Catherine L. Cioffi , David Stover , Brian J. Druker , Elisabeth Buchdunger , Nicholas B. Lydon
DOI:
关键词: Proto-oncogene tyrosine-protein kinase Src 、 Tyrosine kinase 、 Protein tyrosine phosphatase 、 Platelet-derived growth factor receptor 、 Cancer research 、 Biology 、 Receptor tyrosine kinase 、 ROR1 、 Mitogen-activated protein kinase 、 Tyrosine-kinase inhibitor
摘要: … STI571 selectively inhibits the Abl and platelet-derived growth factor (PDGF) receptor tyrosine kinases in vitro and blocks cellular proliferation and tumor growth ofBcr-abl- or v-abl-…
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