The epidemiologic characteristics and clinical course of ophthalmopathy associated with autoimmune thyroid disease in Olmsted County, Minnesota.

摘要: Among incident cases of GO in Olmsted County, Minnesota: affected females six times more frequently than males (86% versus 14% cases, respectively). The age-adjusted incidence rate was 16 per 100,000 population year for and 2.9 males. peak rates were bimodal, occurring the age groups 40 to 44 years 60 64 45 49 65 69 patients with GO, approximately 90% had Graves' hyperthyroidism, 1% primary hypothyroidism, 3% Hashimoto's thyroiditis, 5% euthyroid. Eyelid retraction most common ophthalmic feature autoimmune thyroid disease, being present either unilaterally or bilaterally at some point their clinical course. Exophthalmos one both eyes 60% patients, restrictive extraocular myopathy apparent about 40% optic nerve dysfunction occurred 6% disease. Only complete constellation classic findings: eyelid retraction, exophthalmos, dysfunction, muscle involvement, hyperthyroidism. Upper unilateral bilateral, documented 75% time diagnosis GO. Lid lag also a frequent early sign, 50% initial examination. At ocular symptom pain discomfort, which 30% patients. Some degree diplopia noted by 17% lacrimation photophobia 15% 20% 7.5% complained blurred vision. Decreased vision attributable neuropathy less 2% Thyroid dermopathy acropachy accompanied 4% respectively. Myasthenia gravis Superior limbic keratoconjunctivitis median 43 (range, 8 88). 61% developed ophthalmopathy within 1 onset thyrotoxicosis. Symptoms signs statistically significant changes between final examinations included lacrimation, photophobia, lid lag, fullness, conjunctival injection, chemosis, exophthalmos.(ABSTRACT TRUNCATED AT 400 WORDS)