SUBHYPNOTIC DOSES OF THIOPENTONE AND PROPOFOL CAUSE ANALGESIA TO EXPERIMENTALLY INDUCED ACUTE PAIN

作者： E. ANKER-MØLLER , N. SPANGSBERG , L. ARENDT-NIELSEN , P. SCHULTZ , M.S. KRISTENSEN

关键词: Evoked potential 、 Random order 、 Propofol 、 Nociception 、 Stimulation 、 Medicine 、 Acute pain 、 Threshold of pain 、 Saline 、 Anesthesia

摘要: Subhypnotic doses of thiopentone are considered to have a hyperalgesic effect, while propofol has hypoalgesic effect. We investigated the effect these drugs on nociceptive system by measuring pain threshold laser stimulation and evoked potential (power latency). Nineteen patients (ASA group I) participated. Twelve received 0.5 mg kg−1 0.25 in random order separated an interval 14 h, seven saline. Immediately after injection both agents, was increased significantly (P