IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes.
作者： D T Umetsu , R H DeKruyff , H Secrist , S F Wolf , J D Marshall
DOI:
关键词: Antigen-presenting cell 、 T cell 、 Natural killer T cell 、 Interleukin 12 、 Cytotoxic T cell 、 IL-2 receptor 、 Interleukin 21 、 Immunology 、 Medicine 、 Interleukin 3
摘要: IL-12 influences cytokine synthesis in unprimed CD4+ T cells by enhancing IFN-gamma and the development of Th1 cells, but its effects upon Ag-primed which are thought to have relatively fixed profiles, is less clear. We investigated capacity modify allergen-specific human lymphocytes from allergic donors after vitro stimulation. were obtained peripheral blood subjects with rhinitis, depleted activated cultured APCs allergen. dramatically inhibited IL-4 IL-10 synthesis, while it enhanced cell secretion IL-2, Ag-specific proliferation. The inhibitory effect on was not dependent presence IFN-gamma, greatest when added at initiation culture, minimal late, indicating that resting memory more sensitive than IL-12. APC type, because decreased either B or monocytes served as APCs. These results indicate may be therapeutically beneficial treatment diseases characteristically produce quantities IL-10.
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