Increased oxidative stress is related to disease severity in the ALS motor cortex A PET study

摘要: Objective: To investigate cerebral oxidative stress based on an over-reductive state caused by mitochondrial dysfunction and its relationship to disease severity in patients with amyotrophic lateral sclerosis (ALS) using PET [ 62 Cu]diacetyl-bis( N 4 -methylthiosemicarbazone) ( Cu-ATSM). Methods: Twelve ALS 9 age-matched healthy controls underwent a 20-minute dynamic brain scan after Cu-ATSM injection. The standardized uptake value (SUV) images obtained from the last 10 minutes of frames were normalized global mean (nSUV). Regional retention nSUV was compared between groups statistical parametric mapping (SPM) region interest (ROI) analysis. Secondary analyses evaluated correlations regional nSUVs clinical characteristics participants. Results: In SPM mapping, showed significantly greater accumulation bilateral cortices around central sulcus, including motor cortex, right superior parietal lobule. ROI analysis also revealed than these regions. Increases for regions associated decreases revised Functional Rating Scale score, suggesting good correlation ALS. controls, age correlated although this not observed Conclusions: imaging demonstrated increased state, primarily magnitude well severity, indicating that it may be neurodegenerative changes