5′-Methylthioadenosine Phosphorylase Deficiency in Malignant Cells: Recessive Expression of the Defective Phenotype in Intra-Species (Mouse X Mouse) Hybrids
作者： Naoyuki Kamatani , Masaru Kubota , Erik H. Willis , Dennis A. Carson
DOI: 10.1007/978-1-4757-0390-0_53
关键词: Enzyme 、 Cell culture 、 Phenotype 、 Biology 、 Purine 、 Hypoxanthine Phosphoribosyltransferase 、 Gene 、 Glycogen phosphorylase 、 Purine nucleoside phosphorylase 、 Molecular biology
摘要: In 1977, Toohey reported that some mouse cell lines lacked the recently described purine metabolic enzyme, 5′-methylthio-adenosine (MTA) Phosphorylase (5′-methylthioadenosine:orthophosphate methylthioribosyltransferase)(1). Subsequently, we found same enzyme deficiency in seven out of thirty-one established human malignant lines. contrast, none sixteen benign origin (2).
springer.com
sci-hub.st 参考文章(7)
Dennis A. Carson, Naoyuki Kamatani, Abnormal Regulation of Methylthioadenosine and Polyamine Metabolism in Methylthioadenosine Phosphorylase-deficient Human Leukemic Cell Lines Cancer Research. ,vol. 40, pp. 4178- 4182 ,(1980)
John I. Toohey, Methylthio group cleavage from methylthioadenosine. Description of an enzyme and its relationship to the methylthio requirement of certain cells in culture. Biochemical and Biophysical Research Communications. ,vol. 78, pp. 1273- 1280 ,(1977) , 10.1016/0006-291X(77)91430-9
Naoyuki Kamatani, Dennis A. Carson, Dependence of adenine production upon polyamine synthesis in cultured human lymphoblasts Biochimica et Biophysica Acta. ,vol. 675, pp. 344- 350 ,(1981) , 10.1016/0304-4165(81)90024-6
W. Y. Fujimoto, J. E. Seegmiller, Hypoxanthine-guanine phosphoribosyltransferase deficiency: activity in normal, mutant, and heterozygote-cultured human skin fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 65, pp. 577- 584 ,(1970) , 10.1073/PNAS.65.3.577
Kathleen A. O'Malley, Richard L. Davidson, A new dimension in suspension fusion techniques with polyethylene glycol Somatic Cell Genetics. ,vol. 3, pp. 441- 448 ,(1977) , 10.1007/BF01542972
N. Kamatani, W. A. Nelson-Rees, D. A. Carson, Selective killing of human malignant cell lines deficient in methylthioadenosine phosphorylase, a purine metabolic enzyme Proceedings of the National Academy of Sciences of the United States of America. ,vol. 78, pp. 1219- 1223 ,(1981) , 10.1073/PNAS.78.2.1219
N O Kaplan, S P Colowick, Jagannathan, M D Joshi, Methods in Enzymology , Vol University Of Nairobi. ,(1966)