Inflammation activation and resolution in human tendon disease.

摘要: Improved understanding of the role inflammation in tendon disease is required to facilitate therapeutic target discovery. We studied supraspinatus tendons from patients experiencing pain before and after surgical subacromial decompression treatment. Tendons were classified as having early, intermediate, or advanced disease, was characterized through activation pathways mediated by interferon (IFN), nuclear factor κB (NF-κB), glucocorticoid receptor, signal transducer activator transcription 6 (STAT-6). Inflammation signatures revealed expression genes proteins induced IFN NF-κB early-stage STAT-6 receptor advanced-stage disease. The proresolving FPR2/ALX ChemR23 increased compared intermediate- Patients who pain-free treatment had with CD206 ALOX15 mRNA continued experience treatment, suggesting that these their may moderate pain. Stromal cells diseased cultured vitro showed lipopolysaccharide IFNγ stromal derived healthy tendons. identified 15-epi lipoxin A4, a stable isoform aspirin potentially beneficial resolution inflammation.