Value of postoperative surveillance after radical surgery for colorectal cancer

摘要: PURPOSE: Early detection of recurrence after curative resection for primary colorectal cancer should improve patients' prognosis. However, the usefulness postoperative surveillance programs has not been clarified yet. The present cohort study was aimed at assessing effectiveness systematic follow-up in patients with who were operated on cure, regarding both rate tumor amenable to curative-intent surgery and survival. METHODS: One hundred ninety-nine underwent radical followed according a well-defined program, which consisted laboratory studies (including serum carcinoembryonic antigen assay) every three months, physical examination abdominal ultrasound or computed tomography six chest radiograph total colonoscopy once per year. Cohorts defined compliance proposed program. A multivariate regression model constructed predict RESULTS: forty considered be compliant whereas remaining 59 occasionally attended investigations did comply all. Although there no differences overall (38 vs. 41 percent; P = 0.52), reoperation possible 18 (34 percent) those but only 3 (12 noncompliant (P 0.05). Similarly, probability survival higher cohort, (63 37 percent 5 years; < 0.001) cancer-related (69 49 0.02) rates. Cox analysis disclosed that more advanced TNM stage (odds ratio, 8.17; 95 confidence interval, 1.13-59.29) noncompliance program 2.32; 1.50-3.60) had an independent negative impact CONCLUSION: Systematic cure increases