The role of long non-coding RNA ANRIL in the carcinogenesis of oral cancer by targeting miR-125a
作者： Luyi Chai , Yongping Yuan , Chao Chen , Jianbo Zhou , Yanyan Wu
DOI: 10.1016/J.BIOPHA.2018.01.105
关键词: Long non-coding RNA 、 Carcinogenesis 、 Flow cytometry 、 Cancer research 、 Cancer cell 、 Biology 、 Mir 125a 、 Cancer 、 Cell growth 、 Gene silencing 、 Pharmacology 、 General Medicine
摘要: Abstract Recently, increasing evidence has indicated that lncRNAs may play a critical role in the progression of oral cancer (OC). However, whether lncRNA-ANRIL is involved tumorigenesis OC remains undetermined. In present study, ANRIL showed significantly higher, while miR-125a lower, expression tissues and sera than normal controls. MTT, colony formation, flow cytometry analysis, wound-healing, transwell mice xenograft model assays were used to detect proliferation, migration, invasion ARNIL-overexpressing HB56 cells ARNIL-knockdown CAL27 cells. The results cell increased by ARNIL overexpression decreased silencing Furthermore, we found negative correlation between miR-125a, acts as miRNA-sponge directly interacting with miR-125a.
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