Employment of fucosidases for the synthesis of fucosylated oligosaccharides with biological potential
作者： Francisco Guzmán‐Rodríguez , Sergio Alatorre‐Santamaría , Lorena Gómez‐Ruiz , Gabriela Rodríguez‐Serrano , Mariano García‐Garibay
DOI: 10.1002/BAB.1714
关键词: Transduction (genetics) 、 Immune system 、 Growth regulation 、 Enzyme 、 In vitro 、 Early embryogenesis 、 Biological potential 、 Chemistry 、 Biochemistry 、 Epithelial tissue
摘要: Fucosylated oligosaccharides play important physiological roles in humans, including the immune response, transduction of signals, early embryogenesis and development, growth regulation, apoptosis, pathogen adhesion, so on. Efforts have been made to synthesize fucosylated oligosaccharides, as it is difficult purify them from their natural sources, such human milk, epithelial tissue, blood, Within strategies for its vitro synthesis, remarkable employment fucosidases, enzymes that normally cleave fucosyl residue non-reducing end compounds, these are also capable synthesizing by means a transfucosylation reaction. This review summarizes progress use fucosidases synthesis compounds potential industrial commercial applications.
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