Pharmacogenetic Pathway Analysis for Determination of Sunitinib-Induced Toxicity
作者： Nielka P. van Erp , Karel Eechoute , Astrid A. van der Veldt , John B. Haanen , An K.L. Reyners
关键词: Internal medicine 、 Pharmacogenetics 、 Single-nucleotide polymorphism 、 Toxicity 、 Oncology 、 Candidate gene 、 Leukopenia 、 Medicine 、 Odds ratio 、 Allele 、 Pharmacology 、 Sunitinib
摘要: Purpose To identify genetic markers in the pharmacokinetic and pharmacodynamic pathways of sunitinib that predispose for development toxicities: thrombocytopenia, leukopenia, mucosal inflammation, hand-foot syndrome, any toxicity according to National Cancer Institute Common Toxicity Criteria higher than grade 2. Patients Methods A multicenter pharmacogenetic association study was performed 219 patients treated with single-agent sunitinib. total 31 single nucleotide polymorphisms 12 candidate genes, together several nongenetic variants, were analyzed a possible toxicity. In addition, haplotypes developed related Results The risk leukopenia increased when G allele CYP1A1 2455A/G (odds ratio [OR], 6.24; P = .029) or T FLT3 738T/C (OR, 2.8; .008) present CAG NR1I3 (5719C/T, 7738A/C, 7837T/G) haplotype 1.74; .041) absent. Any 2 prevalence inc...
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CE Carow, M Levenstein, SH Kaufmann, J Chen, S Amin, P Rockwell, L Witte, MJ Borowitz, CI Civin, D Small, Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. Blood. ,vol. 87, pp. 1089- 1096 ,(1996) , 10.1182/BLOOD.V87.3.1089.BLOODJOURNAL8731089
S Misawa, S Horiike, K Kashima, H Kaneko, T Iwai, M Nakao, S Yokota, T Fujimoto, Y Sonoda, Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. ,vol. 10, pp. 1911- 1918 ,(1996)
N. P. van Erp, H. Gelderblom, M. O. Karlsson, J. Li, M. Zhao, J. Ouwerkerk, J. W. Nortier, H.-J. Guchelaar, S. D. Baker, A. Sparreboom, Influence of CYP3A4 Inhibition on the Steady-State Pharmacokinetics of Imatinib Clinical Cancer Research. ,vol. 13, pp. 7394- 7400 ,(2007) , 10.1158/1078-0432.CCR-07-0346
Thomas E. Hutson, Robert A. Figlin, John G. Kuhn, Robert J. Motzer, Targeted Therapies for Metastatic Renal Cell Carcinoma: An Overview of Toxicity and Dosing Strategies Oncologist. ,vol. 13, pp. 1084- 1096 ,(2008) , 10.1634/THEONCOLOGIST.2008-0120
Albert-Jan L.H.J. Aarnoudse, Jeanne P. Dieleman, Loes E. Visser, Pascal P. Arp, Ilse P. van der Heiden, Ron H.N. van Schaik, Mariam Molokhia, Albert Hofman, André G. Uitterlinden, Bruno H.Ch. Stricker, Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration Pharmacogenetics and Genomics. ,vol. 18, pp. 299- 305 ,(2008) , 10.1097/FPC.0B013E3282F70458
Yibo Wang, Yi Zheng, Weili Zhang, Hui Yu, Kejia Lou, Yu Zhang, Qin Qin, Bingrang Zhao, Ying Yang, Rutai Hui, Polymorphisms of KDRGene Are Associated With Coronary Heart Disease Journal of the American College of Cardiology. ,vol. 50, pp. 760- 767 ,(2007) , 10.1016/J.JACC.2007.04.074
A A M van der Veldt, E Boven, H H Helgason, M van Wouwe, J Berkhof, G de Gast, H Mallo, C N Tillier, A J M van den Eertwegh, J B A G Haanen, Predictive factors for severe toxicity of sunitinib in unselected patients with advanced renal cell cancer British Journal of Cancer. ,vol. 99, pp. 259- 265 ,(2008) , 10.1038/SJ.BJC.6604456
Michael P. Epstein, Glen A. Satten, Inference on Haplotype Effects in Case-Control Studies Using Unphased Genotype Data American Journal of Human Genetics. ,vol. 73, pp. 1316- 1329 ,(2003) , 10.1086/380204
Naeem Bhojani, Claudio Jeldres, Jean-Jacques Patard, Paul Perrotte, Nazareno Suardi, Georg Hutterer, François Patenaude, Stéphane Oudard, Pierre I. Karakiewicz, Toxicities Associated with the Administration of Sorafenib, Sunitinib, and Temsirolimus and Their Management in Patients with Metastatic Renal Cell Carcinoma European Urology. ,vol. 53, pp. 917- 930 ,(2008) , 10.1016/J.EURURO.2007.11.037
Naoki Fukui, Yutaro Suzuki, Kazushi Sawamura, Takuro Sugai, Junzo Watanabe, Yoshimasa Inoue, Toshiyuki Someya, Dose-dependent Effects of the 3435 C>t Genotype of abcb1 Gene on the Steady-state Plasma Concentration of Fluvoxamine in Psychiatric Patients Therapeutic Drug Monitoring. ,vol. 29, pp. 185- 189 ,(2007) , 10.1097/FTD.0B013E318038D835