MR and iron magnetic nanoparticles. Imaging opportunities in preclinical and translational research.

摘要: Ultrasmall superparamagnetic iron oxide nanoparticles and magnetic resonance imaging provide a non-invasive method to detect label tumor cells. These exhibit unique properties of superparamagnetism can be utilized as excellent probes for imaging. Most work has been performed using scanner with high field strength up 7 T. may represent suitable tool labeling molecular that target specific tumor-associated markers in vitro vivo detection by In our study, we demonstrated at 1.5 T allows the ultrasmall nanoparticle conjugated antibody specifically bound human cells vivo, signal intensity correlates concentration used antigen density cell surface. The experiments were two different means targeting: direct indirect targeting. antigens immunospecific contrast agents is rapidly evolving field, which potentially aid early disease detection, monitoring treatment efficacy, drug development. Cell emerged powerful monitor trafficking large number therapy field. We also studied natural killer level would allow their clinical Magnetic are able increase accuracy specificity new opportunities preclinical translational research.