FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54.
作者： Michelle K. Clements , Terrence P. McDonald , Ruiping Wang , Guochun Xie , Brian F. O'Dowd
关键词: Biochemistry 、 Central nervous system 、 Orphan G-Protein Coupled Receptor 、 Neuron-derived orphan receptor 1 、 Receptor 、 Gq alpha subunit 、 Cell biology 、 Amino acid 、 Biology 、 Neuropeptide 、 FMRFamide
摘要: Abstract We have isolated and determined the coding sequences of human mouse orthologs rat orphan G-protein-coupled receptor GPR54. Mouse GPR54 are nearly 95% identical to each other, both approximately 85% at amino acid level. Screening agonists for identified several invertebrate neuropeptides RFamide RWamide family that were able activate μM range through Gαq pathway. Substitution analysis showed C-terminal optimal sequence GPR54-activating peptides is Gly-Leu-Arg-Trp-NH2. Northern detected expression in peripheral tissues many regions central nervous system.
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