Haptoglobin: old protein with new functions.

摘要: When released from red blood cells (RBCs), hemoglobin (Hb) is extremely toxic due in large part to the redox activity of its heme center. Nature however, has provided a multitude protective mechanisms that can detoxify free Hb effectively under physiological conditions. Chief amongst them haptoglobin (Hp) which chaperones subunits macrophages for safe degradation. Recent research on interactions between and Hp oxidative conditions revealed specifically shields key amino acids molecule, allowing consume oxidants short-circuits emerging damaging radicals. Moreover, animal studies showed infusion complexed with prevents Hb-induced systemic hypertension tissue injury. It may prove necessary explore these clearing counter toxicity associated when used as oxygen therapeutics hemolytic anemias RBC storage lesions.