Field Evaluation of a Rapid Immunochromatographic Test for Tuberculosis

摘要: Rapid diagnostic tests for tuberculosis (TB) are needed to facilitate early treatment of TB and prevention Mycobacterium transmission. The ICT Tuberculosis test is a rapid, card-based immunochromatographic detection antibodies directed against M. antigens. objective the study was evaluate performance diagnosis active pulmonary (PTB) with whole blood, plasma, serum from patients suspected having PTB asymptomatic controls in setting high prevalence PTB. Seventy (and who were later confirmed have or not by use culture as “gold standard”) 42 studied. Twenty-one neither vaccinated bovis bacillus Calmette-Guerin (BCG) nor tuberculin skin (TST) positive (group A controls), 21 TST and/or had previously been BCG B controls). Study subjects drawn one hospital primary health care unit Rio de Janeiro City, Brazil. One version (ICT-1) evaluated using samples. Sera obtained this frozen tested manufacturer-modified (ICT-2). Among PTB, sensitivities ICT-1 serum, plasma 83, 65, 70%, respectively, specificities 46, 67, 56%, respectively. group controls, three specimen types 95, 100, 95%, 71, 86, 86%, sensitivity ICT-2 70% specificity 65%. among 81%. With 29% observed predictive values ranged 39 50% negative 82 87%. sufficiently warrant their widespread routine setting. However, further evaluation these specific epidemiologic settings may be warranted.