Immunomodulatory constituents from an ascomycete, Microascus tardifaciens.

摘要: Fractionation guided by the immunosuppressive activity of defatted AcOEt extract an Ascomycete, Microascus tardifaciens, afforded eight constituents, questin (emodin 8-O-methylether) (1), rubrocristin (2), 5, 7-dihydroxy-4-methylphthalide (3), cladosporin (asperentin) (4), 8-O-methylether (5), tardioxopiperazine A [cyclo-L-alanyl-5-isopentenyl-2-(1', 1'-dimethylallyl)-L-tryptophan] (6), B [cyclo-L-alanyl-7-isopentenyl-2-(1', (7), and asperflavin (8), among which 6 7 were new compounds. Compounds 1 2 showed considerably high activity, was moderate and, 3, 4, 8 low activity.