Recent Advances in the Synthesis of Unnatural α-Amino Acids

摘要: The synthesis of unnatural  -amino acids is an area research that has gained a lot attention in recent years. availability synthetic methods for novel  amino acid derivatives and related compounds will be critical point the de novo design molecules mimic conformation natural, active peptides. These (peptidomimetics) are designed to display high receptor affinity selectivity, addition enhanced bioavailability metabolic stability. This review focuses on selected methodologies leading including chiral catalysts enable enantioselective microwave-assisted synthesis. Solid phase construction organometallic reveal scope influence this field organic chemistry. Additionally, article aimed provide brief insight into biosynthetic approaches derivatives, give reader appreciation field.