The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia.
作者： Athina Giannoudis , Lihui Wang , Andrea L. Jorgensen , George Xinarianos , Andrea Davies
DOI: 10.1182/BLOOD-2012-01-405035
关键词: Transfection 、 Myeloid leukemia 、 Imatinib mesylate 、 Medicine 、 Single-nucleotide polymorphism 、 Imatinib 、 SNP 、 Pyrosequencing 、 Cancer research 、 Primer (molecular biology)
摘要: … hOCT1 SNPs on imatinib treatment outcome in newly … outcome was M420del (rs35191146), with patients with the M420del demonstrating an increased probability of imatinib treatment …
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