Outcomes of suction curettage and mifepristone abortion in the United States. A prospective comparison study.

作者: Jeffrey T Jensen , Susan J Astley , Elizabeth Morgan , Mark D Nichols

DOI: 10.1016/S0010-7824(99)00016-5

关键词: MedicineObstetricsMedical abortionMisoprostolVacuum CurettageSurgeryCurettageAbortifacientIncomplete AbortionVacuum aspirationAbortion

摘要: A prospective, nonconcurrent cohort analysis of 178 mifepristone/misoprostol and 199 suction curettage abortion subjects, ages > or = 18 years, with intrauterine pregnancies < 63 days estimated gestational age, was conducted to compare the outcomes those medical abortion. The subjects received 600 mg mifeprisone orally, followed by 400 micrograms oral misoprostol 2 later. Surgical underwent electronic vacuum aspiration. All were for weeks until absence clinical bleeding. Outcome measures included a successful (complete without surgical intervention), duration bleeding, morbidity. Overall, 18.3% 4.7% patients failed their primary procedure an unanticipated (RR 3.93, 95% CI 1.87, 8.29). Four mifepristone required acute nine manage ongoing pregnancy, five incomplete Fourteen eight persistent median time delay therapeutic significantly longer in group (35 versus 8 days; Mann-Whitney U 17.0, p 0.008). Medical experienced bleeding (mean difference 9.6 days, 6.8, 12.4). No significant change hemoglobin occurred either group. Mifepristone reported greater pain (77.1% vs 10.5%; RR 7.4, 4.7, 11.5), nausea vomiting (68.6% 0.6%; 117.9, 16.7, 834.7). Women receiving are more likely require unplanned intervention than women who undergo curettage. They experience discomfort follow-up interval, bleed period, remain at risk completion several weeks.

参考文章(20)
Wiebe Er, Abortion induced with methotrexate and misoprostol Canadian Medical Association Journal. ,vol. 154, pp. 165- 170 ,(1996)
Andre Ulmann, Louise Silvestre, Laurence Chemama, Yvonne Rezvani, Marguerite Renault, Claude J. Aguillaume, Etienne-Emile Baulieu, Medical termination of early pregnancy with mifepristone (RU 486) followed by a prostaglandin analogue: Study in 16, 369 women Acta Obstetricia et Gynecologica Scandinavica. ,vol. 71, pp. 278- 283 ,(1992) , 10.3109/00016349209021052
Irving M. Spitz, C. Wayne Bardin, Lauri Benton, Ann Robbins, Early pregnancy termination with mifepristone and misoprostol in the United States. The New England Journal of Medicine. ,vol. 338, pp. 1241- 1247 ,(1998) , 10.1056/NEJM199804303381801
Jesper Legarth, Ulla Britt Schnack Peen, Jane Wilk Michelsen, Mifepristone or vacuum aspiration in termination of early pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology. ,vol. 41, pp. 91- 96 ,(1991) , 10.1016/0028-2243(91)90085-Y
Mitchell D Creinin, Eric Vittinghoff, Eric Schaff, Cynthia Klaisle, Philip D Darney, Catherine Dean, Medical abortion with oral methotrexate and vaginal misoprostol Obstetrics & Gynecology. ,vol. 90, pp. 611- 616 ,(1997) , 10.1016/S0029-7844(97)00266-4
Linda J. Beckman, S. Marie Harvey, Experience and acceptability of medical abortion with mifepristone and misoprostol among U.S. women Womens Health Issues. ,vol. 7, pp. 253- 262 ,(1997) , 10.1016/S1049-3867(97)00117-5
K Joo Thong, Maria H Dewar, David T Baird, What do women want during medical abortion Contraception. ,vol. 46, pp. 435- 442 ,(1992) , 10.1016/0010-7824(92)90147-L
A. Bachelot, L. Cludy, A. Spira, Conditions for choosing between drug-induced and surgical abortions. Contraception. ,vol. 45, pp. 547- 559 ,(1992) , 10.1016/0010-7824(92)90106-4