Unexpected pregnancies exposed to leuprolide acetate administered after the mid-luteal phase for ovarian stimulation

摘要: Leuprolide acetate (Lupron) belongs to the group of gonadotrophin-releasing hormone agonists (GnRHa). It is used in conjunction with human menopausal gonadotrophin (HMG) and/or follicle stimulating (FSH) for ovarian stimulation so-called ultra-short, short or long protocols. In our programme, protocol mainly used, which starts routinely s.c. administration Lupron, 1 mg/day, from day 21 cycle preceding ovum retrieval. After pituitary desensitization achieved, started. However, unexpected, spontaneous pregnancy may occur during flare-up phase Lupron administration. We present six pregnancies and four deliveries have occurred under these circumstances. The mechanisms by escape luteolytic, abortifacient teratogenic effects prolonged use GnRHa are discussed, as well outcome.