The role of nerve growth factor in the prophylaxis and treatment of diabetic foot ulcers.

摘要: Diabetic foot ulcers are still particularly difficult to heal. Therefore, preventing and therapeutic adjuncts increasingly being explored. Nerve growth factor (NGF) is a promising agent exhibiting beneficial actions on both diabetic peripheral neuropathy, one of the main causes ulcers, ulcer healing. Indeed, preclinical research in animal models diabetes has revealed trophic effect NGF small C-fibres, while phase 2 human trials have provided evidence for favourable sensory neuropathy. However, results 3 trial were moderate and, therefore, not enough encourage widespread use treatment Available literature role wound healing sparse but encouraging. Exogenous supplementation or alternative techniques increase its endogenous expression could emerge as protective modality addition standard other factors. The present review provides an outlook prophylaxis ulcers.