Effects of methylprednisolone on peritumoral brain edema. A quantitative autoradiographic study.
作者： Kazuo Yamada , Yukitaka Ushio , Toru Hayakawa , Norio Arita , Noriko Yamada
DOI: 10.3171/JNS.1983.59.4.0612
关键词: Carbohydrate metabolism 、 Blood flow 、 Cortex (anatomy) 、 Blood–brain barrier 、 Vascular permeability 、 Methylprednisolone 、 Anesthesia 、 Peritumoral Brain Edema 、 Medicine 、 Pathology 、 Cerebral blood flow
摘要: Peritumoral brain edema was produced by intracerebral transplantation of Walker 256 tumor in rats. Local cerebral blood flow (LCBF), local glucose utilization (LCGU), and capillary permeability were studied untreated methylprednisolone-treated rats quantitative autoradiography. In the group, LCBF LCGU widely depressed cortex deep structures hemisphere ipsilateral to tumor. animals, significantly better than animals. Capillary highly increased viable part lower that group. These results may suggest increase is major source for fluid production, methylprednisolone improves decreasing Decrease formation result restoration metabolism adjacent tissue, improve clinical symptoms signs.
sci-hub.se 参考文章(15)
Bienvenido D. Ortega, Harry B. Demopoulos, Joseph Ransohoff, Effect of Antioxidants on Experimental Cold-Induced Cerebral Edema Springer, Berlin, Heidelberg. pp. 167- 175 ,(1972) , 10.1007/978-3-642-65448-0_19
D. M. Long, J. F. Hartmann, L. A. French, The response of human cerebral edema to glucosteroid administration. An electron microscopic study. Neurology. ,vol. 16, pp. 521- 521 ,(1966) , 10.1212/WNL.16.5.521
J. D. Weinstein, F. J. Toy, M. E. Jaffe, H. I. Goldberg, The effect of dexamethasone on brain edema in patients with metastatic brain tumors. Neurology. ,vol. 23, pp. 121- 121 ,(1973) , 10.1212/WNL.23.2.121
Y. Matsuoka, K. -A. Hossmann, Corticosteroid therapy of experimental tumour oedema. Neurosurgical Review. ,vol. 4, pp. 185- 190 ,(1981) , 10.1007/BF01743708
Kazuo Yamada, Alfonso M. Bremer, Charles R. West, Effects of dexamethasone on tumor-induced brain edema and its distribution in the brain of monkeys Journal of Neurosurgery. ,vol. 50, pp. 361- 367 ,(1979) , 10.3171/JNS.1979.50.3.0361
H. M. Pappius, Local cerebral glucose utilization in thermally traumatized rat brain Annals of Neurology. ,vol. 9, pp. 484- 491 ,(1981) , 10.1002/ANA.410090511
K A Hossman, M Blöink, Blood flow and regulation of blood flow in experimental peritumoral edema. Stroke. ,vol. 12, pp. 211- 217 ,(1981) , 10.1161/01.STR.12.2.211
Zhao-Ying Yu, Örjan Wrange, Jörgen Boëthius, Ahmad Hatam, Lars Granholm, Jan-Åke Gustafsson, A study of glucocorticoid receptors in intracranial tumors Journal of Neurosurgery. ,vol. 55, pp. 757- 760 ,(1981) , 10.3171/JNS.1981.55.5.0757
H. M. Pappius, Dexamethasone and local cerebral glucose utilization in freeze-traumatized rat brain. Annals of Neurology. ,vol. 12, pp. 157- 162 ,(1982) , 10.1002/ANA.410120205
Ronald Blasberg, Dennis Groothuis, Peter Molnar, Application of Quantitative Autoradiographic Measurements in Experimental Brain Tumor Models Seminars in Neurology. ,vol. 1, pp. 203- 221 ,(1981) , 10.1055/S-2008-1063898