Syntenic relationships between genomic profiles of fiber-induced murine and human malignant mesothelioma.

摘要: Malignant mesothelioma (MM) is an aggressive tumor with a poor prognosis mainly linked to past asbestos exposure. Murine models of MM based on fiber exposure have been developed elucidate the mechanism formation. Genomic alterations in murine now partially characterized. To gain insight into pathophysiology mesothelioma, 16 and 35 human mesotheliomas were characterized by array-comparative genomic hybridization screened for common alterations. Alteration 9p21 region, often biallelic deletion, was most frequent alteration both species, agreement CDKN2A/CDKN2B locus deletion disease models. Other shared aberrations losses 1p36.3–p35 13q14–q33 gains 5p15.3–p13 regions. However, some differences noted, such as absence recurrent mouse regions corresponding chromosome 22. Comparison between altered asbestos-exposed non–asbestos-exposed patients showed significant difference 14q11.2–q21 which also lost fiber-induced mesothelioma. A correlation demonstrated instability tumorigenicity xenografts nude mice. Overall, these data show similarities disease, contribute understanding influence fibers pathogenesis validation model preclinical testing.