Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein

作者: Weijiao Huang , Wooyoung Choi , Wanqiu Hu , Na Mi , Qiang Guo

DOI: 10.1038/CR.2012.24

关键词: AutophagyProtein structureProtein domainCardiolipinLipid bilayerBiologyCell biologyMembrane proteinAromatic amino acidsIn vitroMolecular biology

摘要: … Consistent with these observations, Beclin 1 was … that Beclin 1 null mice die early in embryogenesis and Beclin 1 heterozygous mice develop spontaneous tumors, establishing Beclin 1 …

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