Influence of the hypothalamic paraventricular nucleus (PVN) on heart rate variability (HRV) in rat hearts via electronic lesion.
作者： Xin Deng , Xuhui Feng , Sen Li , Ya Gao , Bingzhi Yu
DOI: 10.3233/BME-151338
关键词: Heart rate variability 、 Sympathetic modulation 、 Medicine 、 Endocrinology 、 Lesion 、 Stimulation 、 Vagal modulation 、 Internal medicine 、 Nucleus 、 Balance (ability)
摘要: Previous literatures have indicated that hypothalamic paraventricular nucleus (PVN) neurons are important for regulating the level of sympathetic and vagal nervous activity. Sympathovagal balance is closely related to heart rate variability (HRV). However, it still requires further elucidation regarding effect PVN on HRV by sympathovagal balance. To detect influence HRV, we evaluated changes in time domain (including standard deviation R-R intervals (SDNN), root mean square successive differences (RMSSD)) frequency low (LFnu), high (HFnu) ratio LF/HF) upon appropriate electronic stimulation, lesions rat vivo. Cardiac modulation was HFnu; LFnu. LF/HF SDNN. Upon stimulating (less than 0.6 mA) rats, found LFnu HFnu changed correspondingly but recovered after stimulation. When rats injured, RR were enhanced with rats' unilaterally or bilaterally injured PVN, especially bilateral lesion. Meanwhile, LFnu, SDNN decreased gradually, accompanied an increase levels. So these may indicate alterations
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