Role of paraventricular nucleus in exercise training-induced autonomic modulation in conscious rats
作者： Samantha Bagolan de Abreu , Adriane Lenhard , Aida Mehanna , Hugo Celso Dutra de Souza , Fernando Morgan de Aguiar Correa
DOI: 10.1016/J.AUTNEU.2009.02.007
关键词:
摘要: Abstract The paraventricular nucleus (PVN) of the hypothalamus is an important site for autonomic regulation, where gamma-aminobutyric acid (GABA) system plays role. central mechanisms underlying modulatory effects exercise training have yet to be characterized. Our objective was analyze on modulation and hemodynamic parameters after bicuculline or muscimol injections into PVN sedentary (control, C) previously submitted swimming (ST) rats. After ST protocol, adult male Wistar rats, instrumented with guide cannulas femoral artery vein catheters were mean arterial pressure (MAP) recording. reduced LF oscillations in normalized units increased HF absolute units. Compared C group, microinjections group promoted a higher decrease MAP (C = − 14 ± 1 vs. ST = − 28 ± 4 mm Hg). Spectral analysis HR (pulse interval) showed that also both groups. Bicuculline systolic (C = 155 ± 5, ST = 164 ± 5 mm Hg) compared group. Meanwhile, only increase oscillations. data has role training.
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