Block by LSD of the Increase in Brain Serotonin Turnover induced by Elevated Ambient Temperature
作者： G. K. AGHAJANIAN , B. L. WEISS
DOI: 10.1038/220795A0
关键词: Serotonin 、 Environmental temperature 、 Metabolite 、 Biophysics 、 Midbrain 、 Chemistry
摘要: AN increased turnover of brain serotonin (5-hydroxy-tryptamine; 5-HT) occurs in rats exposed to high environmental temperature; when the synthesis 5-HT is blocked a more rapid depletion at an ambient temperature 40° C (ref. 1). In addition, concentration principal metabolite 5-HT, 5- hydroxyindoleacetic acid (5-HIAA), this (personal communication from R. K. McDonald). The mechanism activation not known, but similar increase 5-HIAA seen neurones containing (situated caudal midbrain raphe2) are electrically stimulated3,4. It follows that temperatures could result acceleration firing rate 5-HT. (+)-Lysergic diethylamide (LSD) completely inhibits 5). We have given LSD test possibility found these conditions prevented by drug which 5-HT-containing neurones.
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