Effects of immobilization on rat liver tryptophan pyrrolase and brain 5-hydroxytryptamine metabolism.

摘要: 1 . Rat liver tryptophan pyrrolase increased on immobilization. The concentration of 5-hydroxyindoleacetic acid in the brain also rose and that 5-hydroxytryptamine fell. 2 . When adrenalectomized rats were immobilized activity did not rise fell to a lesser extent but as intact animals. 3 . injected with inhibitor Allopurinol both increase fall immobilization less prominent before. affect changes rats. 4 . Immobilization thus appears cause (a) decreased synthesis resulting from induction (b) breakdown by more direct effect brain. Results experiments lysergic diethylamide, α-methyltryptophan or probenecid are consistent above interpretation. 5 . maximal after 5–6 hours' became prolonged immobilization, which suggests regulatory changes.