Preclinical testing of new drugs for tuberculosis: current challenges
作者： Anne J. Lenaerts , Mary Ann DeGroote , Ian M. Orme
DOI: 10.1016/J.TIM.2007.12.002
关键词: Preclinical testing 、 Mycobacterium tuberculosis 、 Intensive care medicine 、 Drug discovery 、 Drug resistance 、 Multiple drug resistance 、 Biotechnology 、 Drug 、 Biology 、 Tuberculosis
摘要: The continuing global epidemic of tuberculosis, the increasing rate multidrug resistant (MDR) tuberculosis and more recent emergence extensively drug (XDR) are great causes for concern. A major international effort is currently underway to optimize current therapies discover new drugs that active against these organisms. This has created a pipeline candidate at various stages preclinical early clinical evaluations. Major challenges still exist, however, varying from standardization application animal models their discovery characterization fact our knowledge about basic biology MDR XDR strains Mycobacterium minimal best.
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