Obstetric and perinatal outcomes of singleton pregnancies conceived via assisted reproductive technology complicated by gestational diabetes mellitus: a prospective cohort study.

摘要: Growing evidence indicates that the risk of obstetric and perinatal outcomes is higher in women with assisted reproductive technology (ART). However, there little known about pregnancy related complications co-morbidity gestational diabetes mellitus (GDM) following singleton pregnancies achieved by ART comparison spontaneous conception (SC). Two hundred sixty pregnant conceived 314 (SC) were participated this prospective cohort study. All participants enrolled after GDM screening through one-step oral glucose tolerance test (OGTT) then grouped into non-GDM groups. Women followed for including pregnancy-induced hypertension (PIH), preeclampsia, antepartum hemorrhage (APH), cesarean section (CS), preterm birth (PTB), intrauterine growth restriction (IUGR), being small or large age (SGA LGA), macrosomia, low weight (LBW), respiratory distress, neonatal hypoglycemia, NICU admission mortality from antenatal visits to delivery. Confounding factors adjusted logistic regression model order estimate odds ratios (aORs). Among 260 SC, 135 152 women, respectively. Higher maternal pre-gravid BMI, shorter duration gestation lower gain observed groups (ART-GDM SC-GDM) compared those SC group. ART-GDM group had a (95% confidence interval) PIH [aOR:7.04 (2.24–22.15)], preeclampsia [aOR:7.78 (1.62–37.47)], APH [aOR:3.46 (1.28–9.33)], emergency CS [aOR:2.64 (1.43–4.88)], such as PTB [aOR:3.89 (1.51–10.10)], LBW [aOR:3.11 (1.04–9.30)] [aOR:4.36 (1.82–10.45)], well hypoglycemia [aOR: 4.91 (1.50–16.07)], SC-GDM showed 4.12 (1.31–12.89)], 2.01 (1.09–3.73] LGA 5.20 (1.07–25.20)], Additionally, 3.46(1.02–11.68), 5.29 (1.03–27.09), 2.53 (1.05–6.09)] SC. Insulin requirement (41.8% vs. 25.7%) was significantly The findings study suggest occurring increases adverse outcomes.