Opioid poorly-responsive cancer pain. Part 1: clinical considerations.
作者： Sebastiano Mercadante , Russell K. Portenoy
DOI: 10.1016/S0885-3924(00)00228-1
关键词: Medicine 、 Neuropathic pain 、 Cancer pain 、 Pain ladder 、 Opioid 、 Cancer 、 Analgesic 、 Bioinformatics 、 Nociception 、 Palliative care 、 Anesthesia
摘要: Pain that is poorly responsive to opioid analgesics challenging for physicians who deal with cancer patients. Numerous factors may influence analgesic response during the course of illness. These include changing nociception associated disease progression, appearance intractable side effects, development tolerance, presence neuropathic pain, temporal pattern, effects produced by production metabolites, and many others. delicate balance between pain relief toxicity must be achieved in patients pain.
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