Hypoxia‐inducible factor as a physiological regulator
作者： Patrick H. Maxwell
DOI: 10.1113/EXPPHYSIOL.2005.030924
关键词: Melanogaster 、 Regulator 、 Hypoxia-Inducible Factor-Proline Dioxygenases 、 Cell biology 、 Transcription preinitiation complex 、 Master regulator 、 Hypoxia-inducible factors 、 Biology 、 HIF1A 、 Homeostasis 、 Bioinformatics
摘要: Hypoxia-inducible factor (HIF) is a transcription complex which responds to changes in oxygen, providing cells with master regulator that coordinates gene transcription. HIF operates all mammalian cell types and ancient evolutionary terms, being conserved C. elegans D. melanogaster. This review summarizes recent insights into the molecular events link reduced oxygenation activation emerging extensive role of broad range physiological processes.
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