Angiogenesis inhibitors. Drug selectivity and target specificity

摘要: The critical role of angiogenesis in tumor development and progression has long been appreciated. elucidation the mechanisms emergence anticancer drugs targeting vasculature a breakthrough treatment several tumors last few years. Several novel molecules are being developed that target different aspects angiogenesis. This review outlines principle anti-angiogenic therapies, illustrates main complexity growth signals involved angiogenesis, its interactions with hypoxia, stroma microenvironment. It provides comprehensive clinical results obtained agents (VEGF/VEGFR signaling inhibitors, direct vascular disrupting agents) finally discusses differences approaches their limitations due to resistance.