Identifying Actionable Targets in Cancer Patients

Guido Reifenberger, Thomas Ruzicka, Marietta Wolter, Julia Reifenberger, Clemens Sommer, Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system Cancer Research. ,vol. 57, pp. 2581- 2585 ,(1997)

Jingwu Xie, Maximilien Murone, Shiuh-Ming Luoh, Anne Ryan, Qimin Gu, Chaohui Zhang, Jeannette M. Bonifas, Ching-Wan Lam, Mary Hynes, Audrey Goddard, Arnon Rosenthal, Ervin H Epstein, Frederic J. de Sauvage, Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature. ,vol. 391, pp. 90- 92 ,(1998) , 10.1038/34201

Maria Arcila, Christopher Lau, Khedoudja Nafa, Marc Ladanyi, Detection of KRAS and BRAF Mutations in Colorectal Carcinoma: Roles for High-Sensitivity Locked Nucleic Acid-PCR Sequencing and Broad-Spectrum Mass Spectrometry Genotyping The Journal of Molecular Diagnostics. ,vol. 13, pp. 64- 73 ,(2011) , 10.1016/J.JMOLDX.2010.11.005

Ervin H. Epstein, Ronald L. Johnson, Robert S. Warren, Matthew P. Scott, Anil G. Menon, Jingwu Xie, John W. Bare, Ling Chun Chen, Fred M. Waldman, Philip H. Cogen, Xiaoli Zhang, Mutations of the PATCHED Gene in Several Types of Sporadic Extracutaneous Tumors Cancer Research. ,vol. 57, pp. 2369- 2372 ,(1997)

Andrea Warrick, Erin M. Forbes, Dylan Nelson, Emily Justusson, Judith Levine, Tanaya L. Neff, Janice Patterson, Ajia Presnell, Arin McKinley, Laura J. Winter, Christie Dewey, Amy Harlow, Oscar Barney, Brian J. Druker, Kathryn G. Schuff, Christopher L. Corless, Carol Beadling, Michael C. Heinrich, Multiplex Mutation Screening by Mass Spectrometry: Evaluation of 820 Cases from a Personalized Cancer Medicine Registry The Journal of Molecular Diagnostics. ,vol. 13, pp. 504- 513 ,(2011) , 10.1016/J.JMOLDX.2011.04.003

R. L. Yauch, G. J. P. Dijkgraaf, B. Alicke, T. Januario, C. P. Ahn, T. Holcomb, K. Pujara, J. Stinson, C. A. Callahan, T. Tang, J. F. Bazan, Z. Kan, S. Seshagiri, C. L. Hann, S. E. Gould, J. A. Low, C. M. Rudin, F. J. de Sauvage, Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma Science. ,vol. 326, pp. 572- 574 ,(2009) , 10.1126/SCIENCE.1179386

Matthew Meyerson, Stacey Gabriel, Gad Getz, Advances in understanding cancer genomes through second-generation sequencing Nature Reviews Genetics. ,vol. 11, pp. 685- 696 ,(2010) , 10.1038/NRG2841

Elaine R. Mardis, Applying next-generation sequencing to pancreatic cancer treatment. Nature Reviews Gastroenterology & Hepatology. ,vol. 9, pp. 477- 486 ,(2012) , 10.1038/NRGASTRO.2012.126

Edward S Kim, Roy S Herbst, Ignacio I Wistuba, J Jack Lee, George R Blumenschein Jr, Anne Tsao, David J Stewart, Marshall E Hicks, Jeremy Erasmus Jr, Sanjay Gupta, Christine M Alden, Suyu Liu, Ximing Tang, Fadlo R Khuri, Hai T Tran, Bruce E Johnson, John V Heymach, Li Mao, Frank Fossella, Merrill S Kies, Vassiliki Papadimitrakopoulou, Suzanne E Davis, Scott M Lippman, Waun K Hong, None, The BATTLE Trial: Personalizing Therapy for Lung Cancer Cancer Discovery. ,vol. 1, pp. 44- 53 ,(2011) , 10.1158/2159-8274.CD-10-0010

Mohamed Bouchahda, Abdoulaye Karaboué, Raphaël Saffroy, Pasquale Innominato, Lee Gorden, Catherine Guettier, René Adam, Francis Lévi, Acquired KRAS mutations during progression of colorectal cancer metastases: possible implications for therapy and prognosis. Cancer Chemotherapy and Pharmacology. ,vol. 66, pp. 605- 609 ,(2010) , 10.1007/S00280-010-1298-9