Applying next-generation sequencing to pancreatic cancer treatment.

摘要: Pancreatic cancer is a highly lethal malignancy that presents multiple technical challenges for genomic studies. Next-generation sequencing and its applications have proven successful in the study of other tumour types, unravelling interplay between DNA RNA changes are unique to tumour. This Review outlines studies performed date explored somatic alterations pancreatic genomes, setting stage introduction our current technological capabilities. In spite several challenging aspects posed by tumours particular clinical sequencing-based diagnostics general, next-generation analysis can now be used experiments relating treatment patients with this disease. As means improve patient outcomes, application comprehensive genomes identify therapeutic options proposed.