Assessment of Intestinal Permeability Using Polyethylene Glycol in Liver Cirrhosis with Ascites

摘要: Increased intestinal permeability and endotoxemia have been implicated in pathogenesis, progression development of complications liver cirrhosis (LC). No study has thus far reported Korea on the assessment using polyethylene glycol (PEG). The aim this was to determine whether is altered LC correlated with clinical characteristics. 65 patients 26 healthy control subjects were studied. value expressed as percentage retrieved PEG 400 3350 that had orally administered 8-hr urine samples determined by high performance liquid chromatography. causes alcohol (n=38), virus (HBV 17, HCV 9) (n= 26) combined HBV (n=1). Mean values for retrieval 46.5±3.22 0.24±0.03 controls, 44.1±5.17 0.21±0.02 without ascites, 37.4±3.55 0.29±0.04 respectively. Intestinal index (IPI) significantly higher ascites than controls or (0.84±0.21 vs. 0.52±0.05 0.54±0.04, p<0.05). A sub-analysis relating Child-Pugh class showed significant differences between , B C IPI (p<0.05). According presence encephalopathy, hypoalbuminemia LC, there (p<0.05), but not indicated prolonged prothrombin time, esophageal varix hyperbilirubinemia. present suggests increased probably importance pathophysiology ascites.