Cyclosporine A-induced autoimmunity: an animal model for human scleroderma

作者: J. Damoiseaux , H. van der Heijden , J. van de Gaar , P. van Breda Vriesman

DOI: 10.1016/S0939-8600(00)80021-8

关键词: Immune deviationPathogenesisAutoimmunitySclerodermaExperimental modelImmunopathologyAutoantibodyAnimal modelPathologyImmunologyMedicineAnimal Science and ZoologyGeneral Veterinary

摘要: Summary Animal models have been shown to be very valuable in the elucidation of pathologic mechanisms complex human diseases. However, conscientious comparison with disease is required define what extend respective model relevant for situation. In this study we compared Cyclosporine A-induced autoimmunity rat scleroderma and hereby taken into account histo- immunopathology, presence vascular abnormalities, occurrence circulating autoantibodies. Altogether, macroscopical histopathological similarities are most important characteristics considering as an experimental scleroderma. Furthermore, T cells macrophages lesions, well peripheral immune deviation within CD4 cell compartment two other common factors they justify use animal further studies on role pathogenesis

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