A dominant role for non‐MHC gene effects in susceptibility to cyclosporin A (CsA)‐induced autoimmunity

摘要: Lethally irradiated LEW rats reconstituted with syngeneic bone marrow and given CsA for a 4-week period develop graft-versus-host-like disease upon withdrawal of CsA. This T cell-mediated autoimmune is referred to as CsA-induced autoimmunity (CsA-AI). CsA-AI-susceptible resistant BN differ greatly in the composition their peripheral cell compartment. To dissect role MHC non-MHC genes development subsets combination susceptibility CsA-AI respective congenic strains (LEW-1N BN-1L) were examined ability CsA-AI. In this study we show that Th1/Th2-like ratio well are under control genes. suggests critical determinant Alternatively, resistance can be attributed lack target organ due absence autoantigen rat strains. interpretation rejected, since both BN-1L consistently characteristic macroscopic microscopic signs adoptive transfer autoreactive LEW-1N cells, respectively. Therefore, it concluded encode immune deviation thereby determine or