MicroRNA expression profile of surgical removed mandibular bone tissues from patients with mandibular prognathism

摘要: Abstract Background Mandibular prognathism (MP) or skeletal class III malocclusion with a prognathic mandible is one of the most severe facial deformities. Recent work has revealed certain circulating microRNAs (miRNAs) are associated MP, we conducted this study to characterize miRNAs expression profile in surgically removed mandibular bone tissue patients MP and explored role miRNA regulation pathogenesis MP. Methods Affymetrix GeneChip 3.0 Array was used examine tissues from control subjects. A variety bioinformatic approaches were predict target genes miRNAs, find potential functions pathways genes, analyze their intersection differentially expressed mRNAs, establish miRNA-gene network. Results Eleven upregulated 11 downregulated fold change ≥2 P value Conclusions Our results indicated possible association between pathogenesis, precise mechanisms needed be further validated.