miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein.

摘要: // Xuchao Zhu 1, * , Dan Li Fei Yu Chengyou Jia 1 Jing Xie Yushui Ma Suyun Fan Haidong Cai Qiong Luo Zhongwei Lv Lihong 2 Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School Shanghai, PR China Respiration, These authors contributed equally to this work Correspondence to: Fan, e-mail: doctorym@126.com Lv, lzwkxy@163.com Keywords: miR-194, non-small cell lung cancer, forkhead box A1 protein Received: October 08, 2015      Accepted: January 23, 2016      Published: February 21, 2016 ABSTRACT Recent studies have implied that miRNAs may play a crucial role in tumor progression and be involved the modulation some drug resistance cancer cells. Earlier demonstrated miR-194 was metastasis (NSCLC), whereas their expression roles on NSCLC still need further elucidation. In current study, we found is decreased samples compared with adjacent non-cancerous samples, low predicts poor patient survival. Both vitro vivo experiments showed ectopic stable suppressed proliferation, migration, invasion induced apoptosis cells suppression could reversed by reintroducing (FOXA1), functional target miR-194. addition, downregulated cisplatin-resisted human line-A549/DDP overexpression increases cisplatin sensitivity. findings suggested inhibits proliferation reverses cisplatin-resistance useful as new potential therapeutic for NSCLC.