Salidroside induces rat mesenchymal stem cells to differentiate into dopaminergic neurons

摘要: Parkinson’s disease (PD) is a neurodegenerative disorder characterised by the loss of substantia nigra dopaminergic neurons that leads to reduction in striatal dopamine (DA) levels. Replacing lost cells transplanting has potential value repair damaged brain. Salidroside (SD), phenylpropanoid glycoside isolated from plant Rhodiola rosea, neuroprotective. We examined whether salidroside can induce mesenchymal stem (MSCs) differentiate into neuron-like cells, and convert MSCs be applied clinical use. induced rMSCs adopt neuronal morphology, upregulated expression marker molecules, such as gamma enolase 2 (Eno2/NSE), microtubule-associated protein (Map2), beta 3 class III tubulin (Tubb3/β-tubulin III). It also increased brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) nerve growth (NGF) mRNAs, promoted secretion these factors. The markers, dopamine-beta-hydroxy (DBH), dopa decarboxylase (DDC) tyrosine hydroxylase (TH), was significantly after treatment with for 1–12 days. DA steadily 1–6 Thus neurons.