The role of cell-released microvesicles in the intercellular transfer of magnetic nanoparticles in the monocyte/macrophage system.

摘要: Mononuclear phagocyte system is the first target for injected nanomaterials. Monocytes/macrophages are central actors trafficking and clearance of magnetic nanoparticles in vivo. However fate nanosized label an ongoing issue. Here we demonstrate that monocyte/macrophage shows a complex dynamic behavior with respect to iron-oxide uptake. Once internalized by monocytes or macrophages, can be released cells upon stress activation. We identified membrane vesicles shed activated apoptotic as carriers transporting These taken up naive macrophages trigger intercellular transfer label. They also lead redistribution during differentiation magnetically-labeled into macrophages. Intercellular label, mediated cell-released vesicles, complicates picture outcome organism their use MRI cell tracers.