Molecular characterization of the env gene from Brazilian field isolates of Bovine leukemia virus.
作者： Marcelo Fernandes Camargos , Ariel Pereda , Daniel Stancek , Maurílio Andrade Rocha , Jenner Karlisson Pimenta dos Reis
DOI: 10.1007/S11262-006-0011-X
关键词: Phylogenetic tree 、 Gene 、 Bovine leukemia virus 、 Biology 、 Infectivity 、 Mutation rate 、 Virology 、 Genetics 、 Epitope 、 Deltaretrovirus 、 Glycosylation
摘要: Molecular characterization of Bovine leukemia virus (BLV) isolates from Brazil using the env gene sequences revealed a high conservation this gene. In most cases substitutions corresponded to silent transitions. addition, cystein residues, potential glycosylation sites, neutralization domains and other critical residues involved with envelope structural viral infectivity were conserved. Most found in aminoacid gp51 protein localized G H epitopes. Using SIFT software, it was predicted that they should not alter functions. Phylogenetic analyses showed partial or complete grouped three four phylogenetic clusters, respectively. The Brazilian had similar mutation rates as compared samples countries, belonged at least two clusters.
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