Regulation of mRNA Stability by AUF1
作者： Gerald M. Wilson , Gary Brewer
DOI: 10.1007/978-1-4757-6446-8_6
关键词: Signal transduction 、 Messenger RNA 、 Protein oligomerization 、 Cell biology 、 Gene expression 、 Heterogeneous nuclear ribonucleoprotein 、 Catabolism 、 Chemistry 、 RNA 、 Gene isoform
摘要: A+U-rich elements (AREs) are potent cis-acting determinants of rapid cytoplasmic mRNA turnover in mammalian cells. Regulation decay rates by these sequences is mediated interaction with cellular factors. Association the protein AUF1 an ARE-containing transcript targets for decay, involving assembly or recruitment a multi-subunit trans-acting complex. In this chapter, recent evidence described which indicates that recognition ARE induces dynamic oligomerization, may serve as scaffold association other factors leading to catabolism RNA substrate. This mechanism targeted complex be regulated at several points, either differential expression individual subunits through activity selected signal transduction pathways. Finally, specific examples where alterations distribution isoforms lead gene during development, and accelerated associated enhanced levels contribute pathogenesis congestive heart failure.
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