Recombinant Lactic Acid Bacteria Secreting OxdC as a Novel Therapeutic Tool for the Prevention of Kidney Stone Disease

摘要: Abstract Kidney stone disease is a dreadful pathological condition, and affects 20% of the population worldwide. The majority renal stones contain calcium oxalate, oxalate has vital role in pathogenesis stone. Humans derive from endogenous production increased intake dietary oxalate. Elevated levels lead to hyperoxaluria, major risk factor for recurrent nephrolithiasis. Current treatment options patients with primary secondary hyperoxaluria are inadequate, do not always significant reduction urinary excretion. Manipulation gut flora potential probiotic bacteria may have positive impact on levels, decrease absorption. Several reports documented microbes capable degrade luminal reduce hyperoxaluria. In addition, decarboxylase gene Bacillus subtilis degrades into CO2 formate, studies proven that administration recombinant lactic acid (LAB) expressing (OxdC) decreased excretion, prevented formation. Thus, degrading LAB heterologous could be beneficial mitigate efficiently by intestinal degradation