Rational methods in the search for antimalarial drugs

摘要: Abstract Largely because of the emergence P. falciparum strains resistant to modern antimalarial drugs such as chloroquine, there is a new surge interest in malaria chemotherapy. Various vitro systems for drug screening are reviewed. There some hope that automated techniques may be value future. Drug mosquito vectors can give useful leads compounds with sporontocidal action, and relatively cheap easy. berghei albino mouse replacing older laboratory models various avian malarias vivo screening. well sensitive lines available screening, resulting data readily interpolated terms chemotherapy infection man. Standardized which must adopted test discussed. The “Quinine Index” should replaced by “Chloroquine Index.” An elaborate follow-up procedure before discovered prepared passed clinical trial.